The No. 16 Syracuse Orange will try to bounce back from their first loss of the season when they
host the Notre Dame Fighting Irish on Saturday at the JMA Wireless Dome in Syracuse,
N.Y. The Orange (6-1) have won six games in a season for the first time since 2018 when they went 10-3.
They are coming off a 27-21 loss at No. 5 Clemson in which they led by 11 points in the fourth quarter.
Meanwhile the Fighting Irish (4-3) are on track to have their worst season since going 4-8 in 2016.
Kickoff is noon ET. The Orange are 2.5-point favorites in the latest Syracuse vs. Notre Dame odds
from Caesars Sportsbook, while the over/under for total points scored is 48. Before making any Notre Dame vs. Syracuse picks,
be sure to check out the college football predictions and betting advice from SportsLine's proven model.
The SportsLine Projection Model simulates every FBS college football game 10,000 times.
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Notre Dame vs. Syracuse spread: Orange -2.5 Notre Dame vs. Syracuse over/under: 48 points
Notre Dame vs. Syracuse money line: Orange -140, Fighting Irish +118 SYR: The Orange rank sixth in the nation in scoring defense (15.1 points per game).