Notre Dame vs. Syracuse prediction, odds, line: 2022 Week 9 college football picks, bets from proven model

The No. 16 Syracuse Orange will try to bounce back from their first loss of the season when they

 host the Notre Dame Fighting Irish on Saturday at the JMA Wireless Dome in Syracuse,

N.Y. The Orange (6-1) have won six games in a season for the first time since 2018 when they went 10-3.

 They are coming off a 27-21 loss at No. 5 Clemson in which they led by 11 points in the fourth quarter.

Meanwhile the Fighting Irish (4-3) are on track to have their worst season since going 4-8 in 2016.

Kickoff is noon ET. The Orange are 2.5-point favorites in the latest Syracuse vs. Notre Dame odds

 from Caesars Sportsbook, while the over/under for total points scored is 48. Before making any Notre Dame vs. Syracuse picks,

be sure to check out the college football predictions and betting advice from SportsLine's proven model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times.

Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,000 for $100 players

 on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

Notre Dame vs. Syracuse spread: Orange -2.5 Notre Dame vs. Syracuse over/under: 48 points

Notre Dame vs. Syracuse money line: Orange -140, Fighting Irish +118 SYR: The Orange rank sixth in the nation in scoring defense (15.1 points per game).

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