NFL odds, lines, picks, spreads, best bets, predictions for Week 6, 2022: Model picking Giants, Packers

Matt Rhule finished last season on the hot seat for the Carolina Panthers,

and he was removed from it when he was fired following the Panthers' 37-15 loss to San Francisco last Sunday.

While a midseason coaching change doesn't portend a strong finish for Carolina, it creates a murky situation for the

Los Angeles Rams when it comes to making Week 6 NFL predictions. The Rams are just 1-4 this season against the

 spread and are the biggest favorites (-10.5) in the Week 6 NFL odds at Caesars Sportsbook. The double-digit line is one of the largest NFL spreads we'll see all season.

The Rams were the latest victim of the Cooper Rush-led Cowboys in Week 5 as 5.5-point home favorites,

but just need to win against Carolina this week to go into their bye at 3-3 straight-up this season

. All of the Week 6 NFL lines are listed below, and SportsLine's advanced computer model has all the NFL

The model, which simulates every NFL game 10,000 times, is up almost $7,000 for $100 players on top-rated NFL

 picks since its inception. The model enters Week 6 of the 2022 NFL season on an incredible 146-106 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and

 beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Top Week 6 NFL predictions One of the model's strongest Week 6 NFL picks is that the Giants (+6) cover the spread at home against the Ravens. 

Top Week 6 NFL predictions New York is one of the most surprising teams this season with 4-1 records overall and against the spread.

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